Consistent with these findings, our recent study also showed that although knockdown of raptor expression markedly inhibits 4E-BP1 phosphorylation, inhibition of AKT activity could further attenuate 4E-BP1 phosphorylation associated with significant antitumor effects in raptor-knockdown colon cancer cells [9]. The gene discussed is EIF4EBP1; the disease is colonic neoplasm.