Taken together, these data suggest that AKT and mTORC1 signaling co-regulate 4E-BP1 phosphorylation, and that 4E-BP1 integrates the effects of AKT and mTORC1 activation on cap-dependent translation, cell proliferation, survival and motility in tumor cells with mutational activation of the PI3K/AKT signaling pathway. Here, EIF4EBP1 is linked to neoplasm.