Joseph et al. demonstrated that forced expression of SEMA3B, but not SEMA3F, inhibited the viability of ovarian cancer cells lines in vitro, and presence of SEMA3F but not SEMA3B significantly inhibited the production of endothelial tubes formed by normal human umbilical vein endothelial cells (HUVEC) in vitro [53]. This evidence concerns the gene SEMA3B and ovarian carcinoma.