In addition, an association was observed between the decrease of the SEMA3B mRNA level and the methylation of the promoter and intronic CpG-islands in ccRCC primary tumors (the Spearman’s correlation coefficient was equal to 0.50 (P < 0.01) for the promoter CpG-island and 0.25 (P < 0.01) for the intronic island). This evidence concerns the gene SEMA3B and nonpapillary renal cell carcinoma.