The Whole miR fingerprint defined by all the miRs contained in Module-1 to Module-4 is associated with the progression of breast carcinoma independently of their HER2 status, as indicated by studies comparing the miR expression profiles in a small cohort of cases consisting of normal mammary gland tissue and matched DCIS, IDC and MET samples. Here, ERBB2 is linked to ductal breast carcinoma in situ.