TM9SF4 and myelodysplastic syndrome: In a study performed in a small subset of acute myeloid leukemia (AMLs) and myelodysplastic syndromes (MDS) characterized by the amplification of a chromosome 20 fragment (20q11.21) bearing among several genes the entire TM9SF4 gene, TM9SF4 mRNA was found overexpressed, thus suggesting a potential role for TM9SF4 in leukemogenesis [17].