After adjustment for age and sex, traditional risk factors such as SBP, BMI, fasting glucose and HOMA-IR, and nontraditional possible confounders such as ALT, endotoxin, hs-CRP, leptin and MDA, the association between IP-10 and disease progression and incident diabetes remained significant (OR 7.84 [95% CI 1.51–40.82]). The gene discussed is GPT; the disease is diabetes mellitus.