Similar results were observed with a combination of MEK and STAT3 inhibitors in K-Ras mutant HCT-116 and LS174T colorectal cancer cells (Figure 6C), which further support the hypothesis that inhibiting dual MEK and STAT3 pathways in K-Ras mutant cells can increase sensitivity to MEK inhibitors. The gene discussed is STAT3; the disease is colorectal cancer.