Through Na+/K+-ATPase regulation[21], EYA4 may participate in the development and maintenance of the hair cells of the inner ear, and analogously, the maintenance of ciliary cells distributing in the inner wall of the eustachian tube could also be impaired by EYA4 mutations, leading to defected tube function and conductive hearing loss[22]. This evidence concerns the gene EYA4 and hearing loss disorder.