CaMKIIγ promoted the cell proliferation via direct activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and multiple oncogenic signaling pathways in non-small cell lung cancer (NSCLC) was found by Chai et al. CaMKIIγ could phosphorylate IκBα kinase β (IKKβ) at Ser177/181 and functioned as a mediator of IKKβ activation in NSCLC. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.