Wang et al. [59] demonstrated that melittin potentiated the TRAIL induced apoptotic effects in human hepatocellular carcinoma cells by activating the CaMKII- transforming growth factor-β-activated kinase 1 (TAK1)- c-Jun N-terminal kinase (JNK)/p38 pathway but inhibiting the IKK-NFκB pathway. The gene discussed is CAMK2G; the disease is hepatocellular carcinoma.