In colon adenocarcinoma cells, CaMKII activates mitogen-activated/extracellular regulated kinase (MEK)/Erk, which is responsible for the phosphorylation and subsequent proteasomal degradation of cyclin-dependent kinase inhibitor 1B (p27Kip1), thus causing the promotion of the S-G2/M transition of cell cycle progression [27]. Here, CDKN1B is linked to colon adenocarcinoma.