In agreement with these results, shortened telomeres are observed in fibroblasts isolated from HGPS patients compared to age-matched controls,23,26 in fibroblasts overexpressing progerin or wild-type lamin A/C24, and in mouse embryonic fibroblasts (MEFs) derived from LMNA deficient mice.27 The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.