In fact, IL-21 supports neoplastic cell proliferation and/or survival in anaplastic large cell lymphoma [92], Hodgkin's lymphoma [93], multiple myeloma [94, 95], Waldenstrom macroglobulinemia [96], adult T cell leukemia/lymphoma [97], cutaneous T cell lymphoma [98], and Sézary syndrome [99]. The gene discussed is IL21; the disease is plasma cell myeloma.