However, another acridone alkaloid arborinin (44) (Figure 3) from Uapaca togoensis displayed strong activities in several cancer cell lines, including MDR phenotypes (Table 1); importantly, hypersensitivity to 44 was reported with CEM/ADR5000 cells (D.R.: 0.11 compared to CCRF-CEM cells), MDA-MB-231/BCRP cells (D.R.: 0.87 compared to MDA-MB-231 cells), and U87MG.ΔEGFR (D.R.: 0.34 compared to U87MG cells) [41]. The gene discussed is ABCG2; the disease is cancer.