FHL1 and Emery-Dreifuss muscular dystrophy: Conversely, select EDMD (K157VfsX36, C273LfsX11, C276Y, and E281Stop) and EDMD/HCM (C209R) FHL-1 mutations result in reduced protein expression when overexpressed in C2C12 cells, suggesting impaired transcriptional regulation and/or protein stability and degradation [272].