Conversely, mouse C2C12 skeletal myoblasts fail to differentiate following downregulation of Bin1 [19, 20], and Bin1 homozygous knock-out mice develop hypertrophic cardiomyopathy leading to perinatal lethality, although skeletal muscles do not exhibit any apparent abnormalities at this stage [21]. Here, BIN1 is linked to hypertrophic cardiomyopathy.