When comparing VWF:VIII factor concentrate with high ratio (Haemate-P) or low ratio (Wilate) in an animal model, a higher cumulative exposure effect with Wilate by 84% was noted, suggesting that these high FVIII levels could be avoided using a concentrate with high ratio [41]; however, this has not been a problem in clinical practice in VWD patients with no accumulation of FVIII or VWF and no thromboembolic events included in the recently reported large experience in children following the administration of 260,000 IU Wilate [31]. The gene discussed is F8; the disease is von Willebrand disease (hereditary or acquired).