F8 and Venous thrombosis: Thompson et al. [26] recommended maintaining a trough VWF:RCo of around 1.0 IU/dL using a twice daily protocol for first 72 hours and then to aim for >0.5 IU/dL thereafter for 7–10 days; furthermore, the aim is to keep FVIII <2.0 IU/dL in view of associated risk of venous thrombosis.