Regarding the prognostic impact of 11q23/MLL translocations in MDS, Solé et al. found a median OS of 26 months and a cumulative risk for developing acute leukemia of 40% to 1 year and 92% to 5 years,54 but did not discriminate between the different types of 11q23/MLL translocations. The gene discussed is KMT2A; the disease is acute leukemia.