IDH1 and acute myeloid leukemia: Our unpublished data confirm the significant better outcome of MDS patients with a der(1;7) as compared with patients with -7 or 7q-.66 Hsiao et al. documented frequent occurrence of previous chemo- or radiotherapy or additional cytogenetic changes in patients with MDS or AML with der(1;7).67 Westman et al. described an increased frequency of isocitrate dehydrogenase (IDH1 and IDH2) mutations in t-MDS/AML patients with der(1;7) and other +1q abnormalities.68