KMT2A and myelodysplastic syndrome: Trisomy 11 affects the MLL gene on 11q23.37 Sixty-four percent of AML and 50% of MDS patients with +11 showed MLL partial tandem duplications (MLL-PTDs).33 Twenty to twenty-five percent of AML with +11, but no MDS patients with this cytogenetic abnormality presented an additional FLT3-ITD mutation.33,38