Corroborating our finding that Sox5 is strikingly up-regulated in TRAF3−/− mouse B lymphomas [54], Sox5 up-regulation has also been documented in DLBCL developed in Brd2 transgenic mice (GEO accession number: GSE6136) [67] and MM developed in XBP-1 transgenic mice (GEO accession number: GSE6980) [68]. The gene discussed is SOX5; the disease is diffuse large B-cell lymphoma.