Here we utilised a model that recapitulates pre-malignant phase of basal-like breast carcinogenesis [34] and found significant alterations in DNA methylation and chromatin modification patterns that were associated with dysregulation of cancer-associated genes and pathways; specifically, genes and loci targeted by, EZH2/polycomb, MYC, AHR and the p53 pathway. The gene discussed is EZH2; the disease is cancer.