In vHMEC, we observed enrichment of up- and down-regulated genes in the MYC and PRC modules, respectively (Figure 2C, D, respectively, family-wise error rate P value <0.05) and no significant change in the CORE module genes (P = 0.06, Additional file 1: Figure S2D), similar to the expression pattern of cancer [26]. The gene discussed is PPRC1; the disease is cancer.