Hypermethylation of the LZTS1 transcription start site did not exhibit an association with expression in TCGA breast tumours; however, FOXA1 (R2 ≤ 0.75 and 0.67 for regions A and B, respectively) and CIRBP (R2 ≤ 0.212) both exhibited loss of expression with increased methylation (Additional file 1: Figure S14). This evidence concerns the gene LZTS1 and breast neoplasm.