EZH2 and cancer: Notably, several key cancer-associated genes were included in the list of deregulated targets, including MYC (hsa-mir-145), EZH2 (hsa-mir199a) and members of the p53 pathway (MDM2 and CDKN1A targeted by hsa-mir-199a and; hsa-mir-519a and hsa-mir-145, respectively).