Notably hypermethylation of these two regions has previously been reported in leukaemia [50], colorectal cancer [51] and pancreatic cancer [52], indicating that they are potential regulatory loci for FOXA1. Given that basal-like cancers and HMEC express low levels of FOXA1, hypermethylation at these regions may play a role in reducing the transcriptional plasticity of the FOXA1 locus. The gene discussed is FOXA1; the disease is colorectal cancer.