Exogenous insulin treatment prevents all signs of hypothyroidism and restores normal free T3 and T4 levels; T3 treatment alone normalizes BT, heart rate and Q-T interval, but has no effect on glycemia [48,49], therefore the reduction of the mean body temperature observed in our work would probably be result of a hypothyroidism secondary to STZ-induced diabetes. Here, INS is linked to hypothyroidism.