Of interest within the context of CIMP, PBRM1 is a SWI/SNF chromatin remodeling complex gene that has been reported to play a tumor suppressor role across multiple cancer types [33], and SETD2 is a histone methyltransferase for H3K36 methylation, which is enriched in the gene bodies of actively transcribed genes [34]. Here, PBRM1 is linked to cancer.