Events with strong effects in more than one tumor type included MGMT and MLH1 promoter methylation, as well as mutation of ARID1A, KRAS, BRAF, and PTEN. Events that were strong but gave mixed results towards the CIMP phenotype included mutation of TP53, PIK3CA, FBXW7, and several amplification and deletion regions. The gene discussed is PTEN; the disease is neoplasm.