E-cadherin (CDH1 gene) is suppressed in several cancer types including pancreatic cancer by its repressors ZEB1 (zinc finger E-box-binding homeobox 1) and SIP1 (Smad-interacting protein 1, ZEB2, and SMADIP1) which thus act as EMT-activators [34–37]. Here, ZEB1 is linked to familial pancreatic carcinoma.