TYK2 and colorectal cancer: The databases showed that HxD-histidine mutants of two tumor suppressors, LKB1 (H174R, COSM mutation ID: COSM27283) and tyrosine kinase 2 (TYK2, H1021Y, COSM mutation ID: COSM20405) have been found in the tumor tissues of lung cancer22 and large intestine cancer patients, respectively.