Two pancreatic cancer cell lines, PANC-1 (poorly differentiated, high level of Vimentin and low level of E-cadherin) and Capan-1 (well-differentiated, high level of E-cadherin and low level of Vimentin), were used to investigate the correlation between acetyl-DNMT1 and DNMT1 in vivo. The gene discussed is VIM; the disease is familial pancreatic carcinoma.