Given the importance of pneumonia as a leading cause of sepsis in critically ill patients in the ICU, we set out to define transcriptional and epigenetic changes at genes encoding components of the Tie2/Ang and Vegfr/Vegf systems in the lung, kidney, and liver in an experimental mouse model of acute lung injury-induced sepsis (ALI-sepsis). The gene discussed is VEGFA; the disease is acute respiratory distress syndrome.