On the other hand, 17 SLQS were mapped onto experimentally defined G-quadruplex-forming regions (determined through deep-sequencing of genomic DNA fragments, extracted from human breast adenocarcinoma cells, that are bound by G-quadruplex-specific antibody (60)), some of which are devoid of PQSL7 motifs (e.g. the segment of Intron 1 of KISS1 gene where G4ST01202430640 is located; Supplementary Figure S2). This evidence concerns the gene KISS1 and breast adenocarcinoma.