Interestingly, EGFP-NBPF1 overexpression arrested the cell cycle in the G1 phase in the two p53-mutant NB cell lines, whereas overexpression of EGFP-NBPF1 in the SH-SY5Y NB cell line, with a wild-type TP53, resulted in a marked sub-G1 peak, indicating induction of cell death (Fig. 10). Here, NBPF1 is linked to neuroblastoma.