Together, these data indicate that NBPF1 overexpression in NB cell lines with non-functional p53 results in G1 cell cycle arrest and induction of CDKN1A, whereas overexpression of NBPF1 in a NB cell line with a wild-type p53 triggers cell death without induction of CDKN1A. Here, NBPF1 is linked to neuroblastoma.