For example, ligation of cell surface GRP78 with α2M* promotes the proliferation of cancer cells in prostate cancer cells, blockade of cell surface GRP78 using the antibody against the COOH-terminal domain of GRP78 reverted the pro-proliferative effect of α2M* [10, 11, 35, 36]. This evidence concerns the gene HSPA5 and Familial prostate cancer.