Nonetheless, taken together these results along with the fact that ANRIL is expressed in cells and tissues that are affected by atherosclerosis [27,40] and are correlated with atherosclerosis severity [25,26], they suggest that ANRIL plays an important role in mediating the genetic effect of the Chr9p21 region on the susceptibility of atherosclerosis. The gene discussed is CDKN2B-AS1; the disease is atherosclerosis.