On the other hand, the function of the CHEK2 protein kinase in the repair of double-strand DNA breaks suggests that BC patients carrying a CHEK2 mutation might have an increased sensitivity to chemotherapeutic agents causing double-strand DNA breaks, such as platinum, alkylating agents and/or anthracyclines (Nevanlinna and Bartek 2006). The gene discussed is CHEK2; the disease is breast cancer.