It has been also shown that CCR7 expression is upregulated in the CNS during both MS and EAE, mostly by activated microglia and DCs (Alt et al. 2002; Columba-Cabezas et al. 2003; Kivisakk et al. 2004; Serafini et al. 2006). The gene discussed is CCR7; the disease is myeloid sarcoma.