To investigate the role of AKT in the proliferation and mobility of PCa cells, DU145 and PC-3 cells were pretreated with a pan-PI3 K inhibitor (LY294002, 50 μM) for 30 min and then incubated in the presence or absence of baicalein (20 μM) for 48 h. Here, AKT1 is linked to posterior cortical atrophy.