EMT also plays a key role in chemoresistance: Zeb1, for example, controls the susceptibility of GBM to temozolomide by disinhibiting the transcription factor c-MYB, a transcriptional activator of the DNA repair enzyme O-6-Methylguanine DNA Methyltransferase (MGMT) [32]. The gene discussed is MYB; the disease is glioblastoma.