APP and breast cancer: In another example (the gene PSEN1, involved in intramembrane proteolysis and cleavage of the intracellular domain of transmembrane proteins such as amyloid precursor protein and Notch and therefore a potential therapeutic target in BC [52]), the ERβ-induced splicing switch did not alter the open reading frame but caused the expression of a longer mRNA (ENST00000366783) compared to the isoform that was favored by ERα (ENST00000422240), possibly affecting the rate of translation or stability of the mRNA.