MYC and acute myeloid leukemia: Mimicking clinical situations, the five AML cell lines had various genetic abnormalities underlying MYC overexpression: single copy gain via trisomy 8 (OCI-AML5 and MUTZ-2), FLT3-ITD mutation and trisomy 8 (MOLM-14 and MV4-11), or MYC amplification (HL-60).