MYC and acute myeloid leukemia: After showing that targeting MYC in murine MYC-overexpressing AMLs prolongs survival (Fig. 2) and that JQ1 demonstrated efficacy against several MYC-overexpressing AML cell lines (Table S1 in electronic supplementary material), we proceeded with preclinical studies using JQ1 in three murine AMLs with mechanisms of MYC overexpression paralleling those seen in human AML.