BM from mice injected with anti-Myc-transduced AML contained very few mCherry+ cells at euthanasia, while BM from mice injected with anti-Renilla-transduced AML contained a high percentage of mCherry+ cells (data not shown), indicating that AMLs transduced with anti-Myc shRNA were less able to predominate in vivo. This evidence concerns the gene MYC and acute myeloid leukemia.