The results showed that AChE activity in HNSCC was significantly lower relative to ANCT in the smokers group (p = 0.017), alcohol drinking group (p = 0.034), moderate and poor differentiation grade (p = 0.030), clinical stage III + IV group (p = 0.033), and lymph node-positive group (p = 0.032) (Table 1). The gene discussed is ACHE; the disease is head and neck squamous cell carcinoma.