The presence in most ANCT specimens of nerve-born PRiMA-linked AChE tetramers (Fig. 4), their lack from glottis- and supraglottis cancerous pieces, and the presence in them of PRiMA-linked BChE tetramers agreed with previous histological observations showing tumour-associated remodelling and loss of nerve terminals along head and neck cancer development and motor nerve invasion [56]. This evidence concerns the gene ACHE and head and neck cancer.