Moreover, the drop of AChE and BChE activities in head and neck cancers and the differences between ANCT and HNSCC pieces in AChE, BChE, nAChR and mAChR mRNA levels lent strong support to the notion that a non-neuronal cholinergic system may be involved in head and neck malignancy. Here, BCHE is linked to head and neck squamous cell carcinoma.