NFKB1 and head and neck squamous cell carcinoma: On the other hand, the well-known capacity of ACh for blocking NFκB production [41, 42] makes it possible that the increased ACh level, arising from the decreased AChE activity in HNSCC and hepatic carcinoma, tightens the blockade of cytokines production, which may provide a tentative explanation for the poor survival prospects of the patients afflicted of HNSCC with low AChE activity.