However, the results indicated that both AChE and BChE activities in serum of HNSCC patients were significantly lower than in the control group (1.09 ± 0.07 mU/ml for AChE and 176.43 ± 9.05 mU/ml for BChE; p < 0.001 and p = 0.007, respectively). This evidence concerns the gene ACHE and head and neck squamous cell carcinoma.