We found that 149 (94.3%) of the 158 analyzed children with HDM allergy had IgE reactivity to at least one of the 7 spotted HDM allergens (nDer p 1, rDer p 2, rDer p 5, rDer p 7, rDer p 10, rDer p 21, and rDer p 23). Here, IGHE is linked to allergic disease.