Comparison of the ImmunoCAP ISAC with other techniques of allergen-specific IgE determinations, such as ImmunoCAP, showed similar diagnostic performances.17-19 Several studies have shown the usefulness of the chip technology for detecting allergen-specific IgE,18 longitudinally assessing IgE reactivity profiles,20 guiding the prescription of specific immunotherapy,21 analyzing allergen-specific IgE and IgG responses in parallel,22 analyzing IgE reactivity in children and adults,23 monitoring IgE reactivities during childhood,24 and predicting the development of allergy in children.25 This evidence concerns the gene IGHE and allergic disease.