In this study, we therefore analyzed immunohistochemical stainings in BXs and RXs of four established tumor suppressors (P53, P16, PTEN and maspin) in viable patient-derived tissue before and after neoadjuvant chemotherapy in order to better understand their changes during chemotherapy, and to find out if this change is related to chemotherapy response or survival. Here, TP53 is linked to neoplasm.