TLR1 and type 2 diabetes mellitus: Apart from the viral signature in T2DM, systemic inflammation was also indicated by the increased transcript expression of S100A12/ENRAGE, corresponding with the reported increased serum levels of S100A12/EN-RAGE in T2DM patients [54], CD164, a HIF-1α-response gene [55], encoding a sialomucin expressed on peripheral blood monocyte, involved in adhesion [56], and TLR1.