In a comparison between T2DM patients and lean controls, the significantly higher expressed genes in T2DM also showed enriched binding sites for HIF1 and ARNT (p = 1 × 10−16 and p = 7.6 × 10−9 respectively), for lower expressed genes HIF1 was again also enriched (p = 7.1 × 10−5, data not shown). This evidence concerns the gene HIF1A and type 2 diabetes mellitus.