Our results are consistent with other studies, which have shown that the content of LXRα decreases after LPS-induced lung injury.10 Interestingly, a similar dynamic of LXRα levels was observed in the livers of mice subjected to CLP,23 supporting the notion that LXRα might be involved in regulating sepsis-related inflammation in a variety of organs. Here, NR1H3 is linked to Sepsis.