Age itself is an independent risk factor for death in patients with severe sepsis.1,33 In support of the clinical observation, several experimental studies have demonstrated that aged animals experience increased severity of the inflammatory response and mortality when compared with younger animals.34, , –37 In our pharmacological studies, in order to investigate the therapeutic efficacy of LXRα activation, we calibrated injury severity in the CLP procedure to produce similar mortality in young and mature adult mice, thus avoiding the potential mortality disadvantage of aged animals. Here, NR1H3 is linked to Sepsis.