When analysis of survival rate was focused only on the initial period of sepsis, we observed that death occurred earlier in young LXRα−/− mice and in both mature adult LXRα+/+ and mature adult LXRα−/− mice when compared with young LXRα+/+ WT animals (P = 0.044 at 36 h after CLP) (Figure 4). The gene discussed is NR1H3; the disease is Sepsis.