CRP and adult-onset Still disease: As shown in Figure 2C and D, AGEs levels significantly declined (mean ± SEM, 24.6 ± 2.7 pg/mL vs. 11.2 ± 1.6 pg/mL, p < 0.001) while sRAGE levels increased (460.5 ± 55.8 pg/mL vs. 794.9 ± 77.0 pg/mL, p < 0.001) significantly, paralleling the decreases in clinical activity scores (5.88 ± 0.41 vs. 2.00 ± 0.20, p < 0.001) and CRP levels (4.07 ± 0.63 pg/ml vs. 0.97 ± 0.26 pg/ml, p < 0.001) in AOSD patients after 6-month therapy.