A missense mutation (L98P) of PSTPIP2 in mice led to pathophysiological changes similar to CRMO, called chronic multifocal osteomyelitis in mice [79] with increased IL-1β secretion in neutrophils and the inflammasome-independent IL-1β-mediated autoinflammatory reactions [80]. The gene discussed is IL1B; the disease is chronic recurrent multifocal osteomyelitis.