HIF1A and neoplasm: The clinicopathologic parameters of UTUC, such as tumor stage, histologic grade, and lymphovascular invasion (LVI), have been reported as independent predictors of clinical outcome following radical surgery [10].Some molecular markers, such as E-cadherin, hypoxia-inducible factor (HIF)-1α, snail, and Ki67 are also independently associated with tumor recurrence and poor survival [11].