The multivariate analysis revealed that sex (P = 0.017), tumor location (P = 0.015), tumor multiplicity (P = 0.002) and KPNA2 expression (P = 0.018) were significantly associated with bladder recurrence (Table 2) and were independent risk factors for bladder recurrence.However, tumor side was marginally significant (P = 0.057) in the multivariate analysis. This evidence concerns the gene KPNA2 and neoplasm.