KPNA2 and renal pelvis/ureter urothelial carcinoma: Moreover, in this study, high expression of KPNA2 was a novel independent predictor for bladder recurrence and poor DFS and OS of UTUC patients after RNU.Further functional studies and prospective validation studies are needed to determine whether KPNA2 is a suitable therapeutic target or whether its high expression can be used as a novel risk factor when selecting UTUC patients who require more aggressive treatment regimens in the clinic.