Third, in the production of tissue microarrays, because of the limitations of pathologic specimens, we did not choose the tumor specimens whose diameter less than 1 cm, and that maybe cause selection bias.Additionally, our study focused on immunoreactivity of KPNA2 by IHC, thus, we did not fully evaluate the associations between KPNA2 immunoreactivity and other reported biomarkers, such as serum C-reactive protein levels [36], or KPNA2 cargo proteins, such as NF-κB p65 or NBS1. Here, RELA is linked to neoplasm.