In particular, ABCC8(ATP-binding cassette, sub-family C (CFTR/MRP), member 8) and KCNJ11(potassium channel, inwardly rectifying subfamily J, member 11) have been the focus of T2DM research over the past two decades due to their possible role in the pathogenesis. The gene discussed is KCNJ11; the disease is type 2 diabetes mellitus.