These co-factors may modulate cancer cell proliferation in gastric and pancreatic adenocarcinomas in a Hh signaling-dependent manner without significant upregulation of Bbf2h7. Co-factors that enhance Hh-Ptch1 binding including BBF2H7 C-terminus, may be good targets for development of novel anticancer drugs that inhibit Hh ligand-dependent growth of cancer cells. Here, CREB3L2 is linked to pancreatic adenocarcinoma.