HGF and colonic neoplasm: MET and HGF are highly expressed in a wide variety of cancers including lung, ovary, renal, gastric, pancreas, head and neck and colon cancers and are also considered to contribute to unregulated cell proliferation, reduced apoptosis, altered cytoskeletal function, tumor cell scattering, migration, dissemination, and invasion during cancer cell metastasis (41–43).