Similarly, the ARID1B gene (AT Rich Interactive Domain 1B), a member of the SWI/SNF chromatin remodeling complex, has been recently associated to cognitive impairment [49] and more specifically to the Coffin-Siris syndrome characterized by intellectual disability, severe speech delay and typical facial features [50, 51]. The gene discussed is SMARCA1; the disease is Coffin-Siris syndrome.