IL10 and infection: As conclusion, this work has established for the first time the antigenicity of the LiPABPs in different forms of natural leishmaniasis, as well as in BALB/c mice infected with L. major. In this model of murine progressive leishmaniasis, the administration of a LiPABPs based vaccine was able to dampen the LiPABP-specific humoral and IL-10 mediated responses detected in the non-vaccinated mice after infection.