S100B and systemic lupus erythematosus: This is line with the recent findings of Brunner who screened biomarkers for the identification of cognitive dysfunction in childhood-onset SLE: (i) anti-NR2A/B antibodies; (ii) S100B (a biomarker of decreased BBB integrity); and (iii) neutrophil gelatinase associated lipocalin, S100A8 and S100A9 (all NET-reported proteomes) were included in the final predictive model with a sensitivity of 100%, specificity of 76% and area under ROC curve of 83.4% [31].