The variants p.Pro428Ala and p.Gly369_Asp370del9 are located close to each other; their LD is high (r2 = 0.98) and their minor alleles are associated with obesity in our sample (OR = 1.27, 95%CI: 1.09–1.47, p = 0.002; pBonferroni corrected = 0.026 and p = 0.003; pBonferroni corrected = 0.039, OR = 1.25, 95% CI: 1.08–1.45, respectively; Table 3) As the LD and proximity of both polymorphisms with the initial lead SNP and the non-synonymous polymorphism rs7498665 (SH2B1: p.Thr484Ala) is very high, the obesity association of all variants are dependent signals. This evidence concerns the gene SH2B1 and obesity due to melanocortin 4 receptor deficiency.