To examine potential approaches towards achieving glioma eradication with T11 target structure as a potent immune stimulator, we develop a mathematical model involving immune components, namely, macrophages, CD8+ T cells, TGF − β and IFN − γ. The sensitivity analysis has been performed on the system parameters, which indicates r1 (growth rate of malignant glioma cells) to be the most sensitive parameter. This evidence concerns the gene CD8A and glioma.