Thus, to investigate whether expression of any one of the two CXCL12 receptors or both in NB tumor cells could influence their selective homing, eGFP+ transduced IGR-NB8 control cells or cell lines overexpressing either CXCR4, CXCR7, or combined receptors, were injected iv in NSG mice. This evidence concerns the gene ACKR3 and neuroblastoma.