BRAF and melanoma: To determine whether this response was unique to angiosarcoma or was a consequence of their MEK dependency, we performed the same experiments in melanoma-derived cell lines that were MEK-dependent (SK-MEL28, which has a BRAF V600E mutation) and MEK-independent (WM-3211, which is BRAF wild-type but contains a c-kit L576P mutation) (Fig. 1B).